RapamycinFungusV1, Main, Exploration, bibRecord, 000781

Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line.

Identifieur interne : 000781 ( Main/Exploration ); précédent : 000780; suivant : 000782

Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line.

Auteurs : Nandakumar Packiriswamy [États-Unis] ; Kari F. Coulson [États-Unis] ; Susan J. Holcombe [États-Unis] ; Lorraine M. Sordillo [États-Unis]

Source :

World journal of gastroenterology [ 2219-2840 ] ; 2017.

RBID : pubmed:28596679

Descripteurs français

KwdFr :
- Animaux (MeSH), Autophagie (MeSH), Caecum (microbiologie), Cellules épithéliales (cytologie), Chimiokines (métabolisme), Cytokines (métabolisme), Côlon (cytologie), Escherichia coli (métabolisme), Espèces réactives de l'oxygène (métabolisme), Humains (MeSH), Inflammation (MeSH), Lignée cellulaire (MeSH), Lignée cellulaire tumorale (MeSH), Maladies inflammatoires intestinales (microbiologie), Maladies inflammatoires intestinales (physiopathologie), Marqueurs biologiques (métabolisme), Microscopie de fluorescence (MeSH), Mitochondries (anatomopathologie), Potentiel de membrane mitochondriale (MeSH), Souris (MeSH), Stress oxydatif (MeSH), Température élevée (MeSH).
MESH :
- anatomopathologie : Mitochondries.
- cytologie : Cellules épithéliales, Côlon.
- microbiologie : Caecum, Maladies inflammatoires intestinales.
- métabolisme : Chimiokines, Cytokines, Escherichia coli, Espèces réactives de l'oxygène, Marqueurs biologiques.
- physiopathologie : Maladies inflammatoires intestinales.
- Animaux, Autophagie, Humains, Inflammation, Lignée cellulaire, Lignée cellulaire tumorale, Microscopie de fluorescence, Potentiel de membrane mitochondriale, Souris, Stress oxydatif, Température élevée.

English descriptors

KwdEn :
- Animals (MeSH), Autophagy (MeSH), Biomarkers (metabolism), Cecum (microbiology), Cell Line (MeSH), Cell Line, Tumor (MeSH), Chemokines (metabolism), Colon (cytology), Cytokines (metabolism), Epithelial Cells (cytology), Escherichia coli (metabolism), Hot Temperature (MeSH), Humans (MeSH), Inflammation (MeSH), Inflammatory Bowel Diseases (microbiology), Inflammatory Bowel Diseases (physiopathology), Membrane Potential, Mitochondrial (MeSH), Mice (MeSH), Microscopy, Fluorescence (MeSH), Mitochondria (pathology), Oxidative Stress (MeSH), Reactive Oxygen Species (metabolism).
MESH :
- chemical , metabolism : Biomarkers, Chemokines, Cytokines, Reactive Oxygen Species.
- cytology : Colon, Epithelial Cells.
- metabolism : Escherichia coli.
- microbiology : Cecum, Inflammatory Bowel Diseases.
- pathology : Mitochondria.
- physiopathology : Inflammatory Bowel Diseases.
- Animals, Autophagy, Cell Line, Cell Line, Tumor, Hot Temperature, Humans, Inflammation, Membrane Potential, Mitochondrial, Mice, Microscopy, Fluorescence, Oxidative Stress.

Abstract

AIM

To determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with inflammatory bowel disease.

METHODS

Normal human colon epithelial cells (ATCC

RESULTS

Exposing CRL.1790 cells to microbial challenge stimulated cells to produce several relevant biomarkers associated with inflammation and oxidative stress. Heat killed cecal contents treatment induced a 10-12 fold increase in IL-8 production by CRL.1790 cells compared to unstimulated controls at 6 and 12 h (

CONCLUSION

The findings from this study suggest that CRL.1790 cells may be a useful alternative to other colon cancer cell lines in studying the mechanisms of oxidative stress events associated with intestinal inflammatory disorders.

DOI: 10.3748/wjg.v23.i19.3427
PubMed: 28596679
PubMed Central: PMC5442079

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Autophagy (MeSH)</term>
<term>Biomarkers (metabolism)</term>
<term>Cecum (microbiology)</term>
<term>Cell Line (MeSH)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Chemokines (metabolism)</term>
<term>Colon (cytology)</term>
<term>Cytokines (metabolism)</term>
<term>Epithelial Cells (cytology)</term>
<term>Escherichia coli (metabolism)</term>
<term>Hot Temperature (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Inflammation (MeSH)</term>
<term>Inflammatory Bowel Diseases (microbiology)</term>
<term>Inflammatory Bowel Diseases (physiopathology)</term>
<term>Membrane Potential, Mitochondrial (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Microscopy, Fluorescence (MeSH)</term>
<term>Mitochondria (pathology)</term>
<term>Oxidative Stress (MeSH)</term>
<term>Reactive Oxygen Species (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Autophagie (MeSH)</term>
<term>Caecum (microbiologie)</term>
<term>Cellules épithéliales (cytologie)</term>
<term>Chimiokines (métabolisme)</term>
<term>Cytokines (métabolisme)</term>
<term>Côlon (cytologie)</term>
<term>Escherichia coli (métabolisme)</term>
<term>Espèces réactives de l'oxygène (métabolisme)</term>
<term>Humains (MeSH)</term>
<term>Inflammation (MeSH)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Maladies inflammatoires intestinales (microbiologie)</term>
<term>Maladies inflammatoires intestinales (physiopathologie)</term>
<term>Marqueurs biologiques (métabolisme)</term>
<term>Microscopie de fluorescence (MeSH)</term>
<term>Mitochondries (anatomopathologie)</term>
<term>Potentiel de membrane mitochondriale (MeSH)</term>
<term>Souris (MeSH)</term>
<term>Stress oxydatif (MeSH)</term>
<term>Température élevée (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term>
<term>Chemokines</term>
<term>Cytokines</term>
<term>Reactive Oxygen Species</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mitochondries</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Côlon</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Colon</term>
<term>Epithelial Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Caecum</term>
<term>Maladies inflammatoires intestinales</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cecum</term>
<term>Inflammatory Bowel Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chimiokines</term>
<term>Cytokines</term>
<term>Escherichia coli</term>
<term>Espèces réactives de l'oxygène</term>
<term>Marqueurs biologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Mitochondria</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Maladies inflammatoires intestinales</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Inflammatory Bowel Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Autophagy</term>
<term>Cell Line</term>
<term>Cell Line, Tumor</term>
<term>Hot Temperature</term>
<term>Humans</term>
<term>Inflammation</term>
<term>Membrane Potential, Mitochondrial</term>
<term>Mice</term>
<term>Microscopy, Fluorescence</term>
<term>Oxidative Stress</term>
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<term>Autophagie</term>
<term>Humains</term>
<term>Inflammation</term>
<term>Lignée cellulaire</term>
<term>Lignée cellulaire tumorale</term>
<term>Microscopie de fluorescence</term>
<term>Potentiel de membrane mitochondriale</term>
<term>Souris</term>
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<front><div type="abstract" xml:lang="en"><p><b>AIM</b>
</p>
<p>To determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with inflammatory bowel disease.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Normal human colon epithelial cells (ATCC</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Exposing CRL.1790 cells to microbial challenge stimulated cells to produce several relevant biomarkers associated with inflammation and oxidative stress. Heat killed cecal contents treatment induced a 10-12 fold increase in IL-8 production by CRL.1790 cells compared to unstimulated controls at 6 and 12 h (</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>The findings from this study suggest that CRL.1790 cells may be a useful alternative to other colon cancer cell lines in studying the mechanisms of oxidative stress events associated with intestinal inflammatory disorders.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28596679</PMID>
<DateCompleted><Year>2018</Year>
<Month>05</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2219-2840</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>23</Volume>
<Issue>19</Issue>
<PubDate><Year>2017</Year>
<Month>May</Month>
<Day>21</Day>
</PubDate>
</JournalIssue>
<Title>World journal of gastroenterology</Title>
<ISOAbbreviation>World J Gastroenterol</ISOAbbreviation>
</Journal>
<ArticleTitle>Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line.</ArticleTitle>
<Pagination><MedlinePgn>3427-3439</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3748/wjg.v23.i19.3427</ELocationID>
<Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">To determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with inflammatory bowel disease.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Normal human colon epithelial cells (ATCC<sup>®</sup>
 CRL.1790™) were stimulated with either heat killed <i>E. coli</i>
 or heat killed murine cecal contents (HKC) and examined for several relevant biomarkers associated with inflammation and oxidative stress including cytokine production, mitochondrial autophagy and oxidant status. TNFα, IL-1β and IL-8 protein concentrations were measured within the supernatants. Fluorescent microscopy was performed to quantify the production of reactive oxygen species (ROS) using an oxidation responsive fluorogenic probe. Mitochondrial morphology and mitochondrial membrane potential was assessed by dual staining using COXIV antibody and a dye concentrating in active mitochondria. Mitochondrial ROS scavenger was used to determine the source of ROS in stimulated cells. Autophagy was detected by staining for the presence of autophagic vesicles. Positive controls for autophagy and ROS/RNS experiments were treated with rapamycin and chloroquine. Mitochondrial morphology, ROS production and autophagy microscopy experiments were analyzed using a custom acquisition and analysis microscopy software (ImageJ).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Exposing CRL.1790 cells to microbial challenge stimulated cells to produce several relevant biomarkers associated with inflammation and oxidative stress. Heat killed cecal contents treatment induced a 10-12 fold increase in IL-8 production by CRL.1790 cells compared to unstimulated controls at 6 and 12 h (<i>P</i>
 < 0.001). Heat killed <i>E. coli</i>
 stimulation resulted in a 4-5 fold increase in IL-8 compared to the unstimulated control cells at each time point (<i>P</i>
 < 0.001). Both heat killed <i>E. coli</i>
 and HKC stimulated robust ROS production at 6 (<i>P</i>
 < 0.001), and 12 h (<i>P</i>
 < 0.01). Mitochondrial morphologic abnormalities were detected at 6 and 12 h based on reduced mitochondrial circularity and decreased mitochondrial membrane potential, <i>P</i>
 < 0.01. Microbial stimulation also induced significant autophagy at 6 and 12 h, <i>P</i>
 < 0.01. Lastly, blocking mitochondrial ROS generation using mitochondrial specific ROS scavenger reversed microbial challenge induced mitochondrial morphologic abnormalities and autophagy.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The findings from this study suggest that CRL.1790 cells may be a useful alternative to other colon cancer cell lines in studying the mechanisms of oxidative stress events associated with intestinal inflammatory disorders.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Packiriswamy</LastName>
<ForeName>Nandakumar</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Nandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Coulson</LastName>
<ForeName>Kari F</ForeName>
<Initials>KF</Initials>
<AffiliationInfo><Affiliation>Nandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Holcombe</LastName>
<ForeName>Susan J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Nandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sordillo</LastName>
<ForeName>Lorraine M</ForeName>
<Initials>LM</Initials>
<AffiliationInfo><Affiliation>Nandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States.</Affiliation>
</AffiliationInfo>
</Author>
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</PublicationTypeList>
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<MedlineTA>World J Gastroenterol</MedlineTA>
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<ISSNLinking>1007-9327</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
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<NameOfSubstance UI="D018925">Chemokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D002432" MajorTopicYN="N">Cecum</DescriptorName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018925" MajorTopicYN="N">Chemokines</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003106" MajorTopicYN="N">Colon</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
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Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line.

Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line.

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